Volume : 6
Issue : 1
Antibiotic susceptibility pattern of Burkholderia cepacia complex from various clinical samples in a tertiary care center: A one year prospective study
Ratna Shukla, Anil K Bilolikar, Udayasri B, Pragya Rani
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Ratna Shukla1,*, Anil K Bilolikar1, Udayasri B1 and Pragya Rani1
1Department of Microbiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India
*Corresponding author: Dr. Ratna Shukla, Department of Microbiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Email: firstname.lastname@example.org
Received 05 October 2017; Revised 17 November 2017; Accepted 30 November 2017; Published 08 December 2017
Citation: Shukla R, Bilolikar AK, Udayasri B, Pragya Rani. Antibiotic susceptibility pattern of Burkholderia cepacia complex from various clinical samples in a tertiary care center: A one year prospective study. J Med Sci Res. 2018; 6(1):1-5. DOI: http://dx.doi.org/10.17727/JMSR.2018/6-1
Copyright: © 2018 Shukla R et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Background: The Burkholderia cepacia complex (BCC) is a diverse group of human pathogens that cause life-threatening infections in patients with indwelling devices & those requiring intensive care. The aim of this study is to determine the antibiotic susceptibility pattern of Burkholderia cepacia complex (BCC) from various clinical samples in our hospital.
Material and methods: In this one year prospective study conducted in the Department of Microbiology at Krishna Institute of Medical Sciences Limited, Secunderabad; various samples received over the year were cultured. Identification and antibiotic susceptibility testing of BCC was done by using automated Vitek® 2 Compact system (BioMérieux).
Results: Out of total 4900 culture positive isolates; 43 (0.9%) Burkholderia cepacia complexes were isolated. Majority isolates were from blood 18 (41.8%) followed by respiratory samples 15 (34.8%). BCC showed maximum susceptibility to ceftazidime (72.1%) and minocycline (55.8%). Maximum resistance was seen with β–lactamase inhibitor drugs (83.7%).
Conclusion: BCC being a nosocomial agent with high mortality poses a real threat in critically ill patients and needs prompt treatment and infection control.
Keywords: Burkholderia cepacia complex; multi-drug resistance; Vitek 2