Volume : 7
Issue : 2
Clinicopathological spectrum of patients with lupus nephritis in a tertiary care hospital
Harika Venishetty, Sujatha Poduval K, Satish Rao I, Reddy VS
Pdf Page Numbers :- 36-42
Harika Venishetty1,*, Sujatha Poduval K1, Satish Rao I1, and Reddy VS2
1Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India
2Department of Nephrology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India
*Corresponding author: Dr. Sujatha Poduval K, Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Email: firstname.lastname@example.org
Received 21 January 2019; Revised 7 March 2019; Accepted 18 March 2019; Published 26 March 2019
Citation: Venishetty H, Poduval KS, Satishrao I, Reddy VS. Clinicopathological spectrum of patients with lupus nephritis in a tertiary care hospital. J Med Sci Res. 2019; 7(2):36-42. DOI: http://dx.doi.org/10.17727/JMSR.2019/7-8
Copyright: © 2019 Venishetty H et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
View Full Text
Aim: The aim is to determine the distribution of different classes of lupus nephritis based on renal biopsy and to correlate it with serum creatinine and proteinuria.
Objectives: To study the prevalence of different classes of systemic lupus erythematosus (SLE) using the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification in our facility, and to determine the correlation between the histopathological features of different classes of lupus nephritis and the clinical and laboratory parameters.
Material and methods: Renal biopsy specimens with a clinical diagnosis of SLE by ARA criteria in a period of 3 years received in the laboratory were included in the study and were classified according ISN/RPS 2003 classification. The clinical and laboratory data were obtained from patient files.
Results: Out of 40 patients, 35 (88%) were females and 5 (12%) were male patients. Mean age was 32.7±10.7 years. Majority of patients belong to class IV (53%) followed by class III (22%).
Conclusion: In this study the commonest class of International Society of Nephrology (ISN)/Renal Pathology Society (RPS) classification is class IV and there is significant correlation between 24 h proteinuria with ISN/RPS classes.
Keywords: Systemic lupus erythematosus; lupus nephritis; nephritic syndrome; autoimmune