Volume : 8
Issue : S1
Tocilizumab treatment and outcomes in severe COVID-19 patients: Retrospective study from a tertiary care institute in western India
Peta RK, Panchal HP, Patel A, Parikh S, Khanikar D, Himthani N
Pdf Page Numbers :- 6-10
Ravindra Kumar Peta1,*, Harsha P Panchal1,*, Apurva Patel1, Sonia Parikh1, Duncan Khanikar1, and Nikhil Himthani1
1Department of Medical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India
*Corresponding authors: Dr. Harsha P Panchal, Prof and HOD, Department of medical oncology, The Gujarat Cancer REsearch Institute, Ahmedabad, Gujarat, India. Mobile: +91 9825940769; Email: email@example.com. Dr. Ravindra Kumar Peta (DM Medical oncology), Resident, Department of Medical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Mobile: +91 9023739722; Email: Ravindra0504090@gmail.com
Received 24 September 2020; Revised 9 November 2020; Accepted 17 November 2020; Published 25 November 2020
Citation: Peta RK, Panchal HP, Patel A, Parikh S, Khanikar D, Himthani N. Tocilizumab treatment and outcomes in severe COVID-19 patients: Retrospective study from a tertiary care institute in western India. J Med Sci Res. 2020; 8(S1):6-10. DOI: http://dx.doi.org/10.17727/JMSR.2020/8S1-1
Copyright: © 2020 Peta RK et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Background: Coronavirus disease 2019 (COVID-19) is a pandemic caused by a novel beta coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV-2). The symptoms range from mild to severe in nature. The severity of respiratory symptoms is due to the cytokine storm. The tocilizumab, interleukin-6 inhibitor, can prevent the cytokine release and decrease the mortality.
Patients and methods: This is a retrospective observational study of 20 COVID-19 positive cases who received tocilizumab.
Results and conclusion: There were 75% males with a mean age of 47.20±9.68 years in our study. 50% had diabetes mellitus, 35% had hypertension, 5% had Chronic kidney disease, 5% had obesity and 5% had hypothyroidism. Mortality was reduced to 65% with tocilizumab administration. There was statistically significant reduction of C- reactive protein (p<0.00052) and IL-6 (interleukin) (p<0.023) after administration of tocilizumab.
Keywords: tocilizumab; interleukin-6; COVID-19; C-reactive protein