Volume : 10
Issue : 2
Role of routine laboratory markers in the diagnosis of rotavirus and adenovirus gastroenteritis
Kılıçaslan O, Sav NM, Karaca S, Şahin IE, Öksüz S, Kocabay K
Pdf Page Numbers :- 76-81
Önder Kılıçaslan1,*, Nadide Melike Sav2, Seda Karaca1, İbrahim Ethem Şahin3, Şükrü Öksüz4, and Kenan Kocabay1
1Department of Child Health and Diseases, Faculty of Medicine, Duzce University, Turkey
2Department of Pediatric Nephrology, Faculty of Medicine, Duzce University, Turkey
3Department of Medical Biochemistry, Faculty of Medicine, Duzce University, Turkey
4Department of Medical Microbiology, Faculty of Medicine, Duzce University, Turkey
*Corresponding author: Önder Kılıçaslan, Medical Doctor, Department of Child Health and Diseases, Faculty of Medicine, Duzce University, Turkey. Tel.: 905065962784; Email: firstname.lastname@example.org
Received 21 December 2021; Revised 28 February 2022; Accepted 10 March 2022; Published 19 March 2022
Citation: Kılıçaslan O, Sav NM, Karaca S, Şahin IE, Öksüz S, Kocabay K. Role of routine laboratory markers in the diagnosis of rotavirus and adenovirus gastroenteritis. J Med Sci Res. 2022; 10(2):76-81. DOI: http://dx.doi.org/10.17727/JMSR.2022/10-15
Copyright: © 2022 Kılıçaslan O et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Purpose: The present study aimed to evaluate and estimate the additional and auxiliary diagnostic value of routine laboratory parameters in patients with acute diarrhea caused by rotavirus and adenovirus.
Methods/ patients: A total of 6784 patients diagnosed with acute gastroenteritis were evaluated. Rotavirus and adenovirus infection was diagnosed via a Qualitative immunochromatographic combo rapid cassette antigen test. Complete blood count and biochemical blood tests were performed in all the patients and were compared between the groups according to the positivity or negativity of the virus.
Results: Rotavirus diarrhea was diagnosed in 16.8% and adenovirus diarrhea in 3.2% of patients. Hemoglobin, hematocrit, and mean cell volume (MCV) levels were lower, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly higher in rotavirus positive cases. Neutrophil to lymphocyte ratio was significantly higher, and lymphocyte to monocyte ratio was significantly lower in positive rotavirus cases than negative ones 2.96 and 2.56, respectively (p<0.001).
Conclusions: Hematological and biochemical parameters may assist in diagnosing and distinguishing rotaviral and adenoviral gastroenteritis, especially in low-resource environments.
Keywords: adenovirus; children; diarrhea; laboratory markers; rotavirus