Orginal Research
2022 December
Volume : 10 Issue : 4

Migraine and vitamin D levels and the severity of headache in children

Enugala R, Nadeem SM, Patel B, Rao BS, Malapati B

Pdf Page Numbers :- 212-215

Ravikiran Enugala1, Shaikh Mohammed Nadeem2, Bhavita Patel3, Srinivasa Rao B4 and Brahmareddy Malapati3,*


1Department of Biochemistry, Krishna Mohn Medical College and Hospital, Mathura, Uttar Pradesh-281001, India

2Department of Biochemistry, Dr. S.S. Tanita Medical College, Sri Ganganagar, Rajasthan-335001, India

3Department of Biochemistry, Dr. Kiran C Patel Medical College, Bharuch, Gujarat-392001, India

4KIMS Foundation and Research Centre, Minister Road, Secunderabad - 500003, Telangana, India


*Corresponding author: Dr. Brahmareddy Malapati, Associate Professor, Department of Biochemistry, Dr. Kiran C Patel Medical College and Research Institute, Bharuch, Gujarat-392001, India. Email:


Received 9 July 2022; Revised 10 September 2022; Accepted 20 September 2022; Published 29 September 2022


Citation: Enugala R, Nadeem SM, Patel B, Rao BS, Malapati B. Migraine and vitamin D levels and the severity of headache in children. J Med Sci Res. 2022; 10(4):212-215. DOI:


Copyright: © 2022 Enugala R et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Introduction: A migraine is a condition where there is a headache that can cause severe throbbing paining or a pulsing sensation of pain on unilateral side of the head. It is a primary episodic headache disorder which is due to neurological, gastrointestinal, central nervous system and autonomic changes. The prime aim of the study was to determine the levels of vitamin D associated with the severity of headache in patients with migraine.

Methods: A total number of 108 children diagnosed with migraine were evaluated. Levels of vitamin D and 25-hydroxy vitamin D3 were measured by using ELISA method (enzyme-linked immunoassay). Serum vitamin D levels were defined as 30ng/ml. The severity of the headache was determined according to the MIDAS (Migraine Disability Assessment Score).,

Results: The mean serum 25-hydroxy vitamin D3 levels of migraine patients were 18.6±4.9 ng/ml. As the level of vitamin D decreased, so the severity of the headache increased, with a higher Migraine Disability Assessment score grade (p 0.05) which shows closer inverse proportional association of vitamin-D levels with migraine.

Conclusion: The high levels of headache are associated with reduced serum vitamin D levels in children with migraine.


Keywords: migraine; vitamin D; headache; children