Ramipril induced pemphigoid vulgaris

Mustafa Ali Mirza, Suryakanth Jena

Pdf Page Numbers :- 122-124

Mustafa Ali Mirza^1,* and Suryakanth Jena¹

¹Department of Cardiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

*Corresponding author: Mustafa Ali Mirza, Clinical Research Coordinator, Department of Cardiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Mobile: +91 8523052865; Email: alimirza2395@gmail.com

Received 9 July 2018; Revised 18 August 2018; Accepted 1 September 2018; Published 8 September 2018

Citation: Mirza MA, Jena S. Ramipril induced pemphigoid vulgaris. J Med Sci Res. 2018; 6(4):122-124. DOI: http://dx.doi.org/10.17727/JMSR.2018/6-20

Copyright: © 2018 Mirza MA et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Introduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to angiotensin II and also inhibits bradykinin metabolism thereby causing dilation of arteries and veins. These actions bring about reduction in preload and afterload on heart. Side effects of ACE inhibitors include cough, dysgeusia, hyperkalaemia, renal failure, proteinuria, agranulocytosis etc. Seldomly ACE inhibitors precipitate skin rashes, pruritus & urticaria.

Case report: A 52-year-old female with known case of rheumatoid arthritis was prescribed ramipril for treatment of cardiomegaly and left ventricular (LV) dysfunction. The patient reported skin related adverse drug reaction i.e., pemphigoid vulgaris.

Conclusion: From the current case report it can be said that ramipril can cause and aggregate some rare skin adverse effects as that of pemphigoid vulgaris which can be reversed within a short span of time if recognized early.

Keywords: ramipril; angiotensin-converting enzyme; pemphigoid vulgaris