Review
2014 June
Volume : 2 Issue : 2


Role of TGF-β signaling in tumorigenesis

Venkateshwari A, Vinod C, Pratibha Nallari A, Jyothy A

Pdf Page Numbers :- 113-118

Venkateshwari A1, Vinod C1,2,  Pratibha Nallari A1 and Jyothy A1,*

 

1Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet,   Hyderabad – 500 016, India

 

2KIMS Foundation and Research Centre, Krishna Institute of Medical Sciences, Minister Road, Secunderabad – 500003, AP., India

 

*Corresponding author: Dr. A. Venkateshwari, Department of Cell Biology,  Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad – 500 016, India. Tel: 091-40-23403681; Email: venkateshwari@yahoo.com

 

Received 24 January 2014; Revised 27 February 2014; Accepted 12 March 2014

 

Citation: Venkateshwari A, Vinod C,  Pratibha Nallari A, Jyothy A. Role of TGF-β signaling in tumorigenesis. J Med Sci Res 2014; 2(2):113-118. DOI: http://dx.doi.org/10.17727/JMSR.2014/2-020  

 

Copyright: © 2014 Venkateshwari A et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Transforming growth factor β (TGF β) is one of the crucial cytokine playing an important role in developmental and pathological conditions. TGF β is primarily Smad mediated signal transducers but it can also cross talk with  c-Jun N-terminal kinases (JNK), Mitogen-activated protein kinases (MAP), Phosphoinositide 3 (PI-3) kinase, Akt/protein kinase B signaling pathways  to enhance cancer development. During early stages of cancer the TGF β induces a protective cytostatic effect.  In advanced stages, TGF β fails to down regulate Myc, a transcription factor which represses expression of p21Cip1 and p15Ink4b involved proliferation and differentiation of normal epithelial cells and thus losses its cytostatic property. TGF β also involves in various metastatic processes including angiogenesis, extracellular modification, epithelial-mesenchymal transition, cell migration, immune suppression.  Several preclinical animal model studies have encouraging outcomes, suggesting TGF β as a potential therapeutic target in advanced cancers.

 

Keywords: Transforming growth factor β; Smad; c-Jun N-terminal kinase; Mitogen-activated protein kinase; Phosphoinositide 3 kinase

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