Study of bone markers in hyperthyroidism: Single centre experience from south India

Babulreddy Hanmayyagari, Mounika Guntaka, Rakesh Sahay, Ramesh Jayanthy, Nagesh Sri

Pdf Page Numbers :- 53-56

Babulreddy Hanmayyagari^1,*, Mounika Guntaka², Rakesh Sahay³, Ramesh Jayanthy³ and Nagesh Sri⁴

¹Department of Endocrinology, Krishna Institute of Medical Sciences, Kondapur, Hyderabad -500084, India

²Department of Biochemistry, Chalmeda Anand Rao Institute of Medical Sciences, Bommakal, Karimnagar, Telangana 505001, India

³Department of Endocrinology, Osmania general hospital, Hyderabad-500012, India

⁴Department of Endocrinology, Care Hospital, Banjara hills, Hyderabad, India

*Corresponding author: Dr. H. Babul Reddy, Department of Endocrinology, Krishna Institute of Medical Sciences, Kondapur, Hyderabad - 500084, India. Mobile: +91 9985661434; Email: babulreddy78@gmail.com

Received 20 January 2015; Revised 10 March 2015; Accepted 17 March 2015; Published 24 March 2015

Citation: Babulreddy H, Mounika G, Rakesh S, Ramesh J, Nagesh S. Study of bone markers in hyperthyroidism: Single centre experience from south India. J Med Sci Res. 2015; 3(2):53-56. DOI: http://dx.doi.org/10.17727/JMSR.2015/3-010

Copyright: © 2015 Babulreddy H, et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Aim: To evaluate bone health markers and vitamin D status in patients with hyperthyroidism comprehensively, and comparison of same with matched controls.

Materials and methods: The study has been done on 30 newly diagnosed hyperthyroid patients and matched controls. Cases were selected after careful exclusion of conditions which adversely affect bone health. Statistical comparisons were performed with Student’s t test.

Results: The study group has shown normal calcium (20% had hypocalcemia), normal phosphorus, normal PTH values, raised alkaline phosphatase levels & significant rise in both bone formation (Osteocalcin) and resorption (β-cross laps) markers (P<0.05). In addition 95% of our subjects (patients and controls) were vitamin D deficient (mean-17.2 ng/dl). There is no specific increase in vitamin D deficiency in hyperthyroidism patients.

Conclusion: Hyperthyroidism is associated with increased rate of bone remodeling & changes in mineral homeostasis, thereby increases risk of fractures. Associated vitamin D deficiency further deteriorates bone quality. So it is suggested therapeutic vitamin D and calcium supplementation in addition to antithyroid medication.

Keywords: hyperthyroidism; vitamin D; osteocalcin; β-crosslaps