Original Research
2021 December
Volume : 9 Issue : 4


Trace elements and antioxidant status in human immunodeficiency virus positive patients

Malapati B, Nadeem SM, Shaker IA, Patel B

Pdf Page Numbers :- 211-216

Brahmareddy Malapati1, Shaikh Mohammed Nadeem1, Ivvala Anand Shaker2, and Bhavita Patel3,*

 

1Department of Biochemistry, Dr. Kiran C Patel Medical College, Bharuch, Gujarat-392001, India

2Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Limda, Waghodia-391760, Gujarat, India

3Department of Biochemistry, NAMO Medical Education and Research Institute, Silvassa, Dadra and Nagar Haveli and Daman and Diu-396230, India

 

*Corresponding author: Dr. Bhavita Patel, Assistant Professor, Department of Biochemistry, NAMO Medical Education and Research Institute, Silvassa, Dadra and Nagar Haveli and Daman and Diu-396230, India. Email: patel.bhavita2014@gmail.com

 

Received 8 June 2021; Revised 30 August 2021; Accepted 9 September 2021; Published 17 September 2021

 

Citation: Malapati B, Nadeem SM, Shaker IA, Patel B. Trace elements and antioxidant status in human immunodeficiency virus positive patients. J Med Sci Res. 2021; 9(4):211-216. DOI: http://dx.doi.org/10.17727/JMSR.2021/9-32

 

Copyright: © 2021 Malapati B et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Objectives: This study was conducted to determine the plasma levels of the antioxidants and mineral trace elements in three severity groups of human immunodeficiency virus (HIV) patients compared with non-HIV-infected controls.

Methods: The plasma levels of antioxidants (Total antioxidant, albumin, bilirubin, uric acid) and trace elements (Mg, Fe, Zn, Mn, Cu, Cr, Cd and Se) were estimated in spectrophotometrically in controls and patients with CD4 counts <200; 200–499 and ≥500 cells/µL.

Results: Plasma uric acid and plasma zinc (Zn) were significantly high, while vitamin E and all the micro trace elements (except Zn) were significantly lower in HIV-infected patients compared to healthy controls human beings. The higher level of plasma uric acid was observed in those with CD4 counts <200 cells/µL. All the trace elements (except Zn) were high levels in HIV subjects with a CD4 count of 200–499 cells/µL compared to >500 cells/µL. Only plasma uric acid and zinc showed significant correlation with CD4 cell count.

Conclusion: Routine assessment of antioxidant/ trace element levels in HIV subjects is recommended. This supplementation is given to strengthen the immune system and reduce the adverse consequences of HIV related oxidative stress and sometimes suggests that assessing antioxidant levels or enzymes activities of patients infected with HIV should be considered during therapy.

 

Keywords: trace elements; human immunodeficiency virus; antioxidants; CD4 cell; AIDS; oxidative stress

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