Utility of immunohistochemistry in the diagnosis of bone tumors

Sailaja M, Satish Rao

Pdf Page Numbers :- 84-90

Sailaja M^1,* and Satish Rao¹

¹Department of Laboratory Medicine, Krishna Institute of Medical sciences, Minister Road, Secunderabad - 500003, AP, India

*Corresponding author: Dr. M. Sailaja, MD (Pathology), Consultant Pathologist, Department of Laboratory Medicine, Krishna Institute of Medical sciences, Minister Road, Secunderabad - 500003, AP, India. Email: drsailaja_mreddy@yahoo.in

Received 23 January 2014; Revised 20 February 2014; Accepted 6 March 2014

Citation: Sailaja M, Satish Rao I. Utility of immunohistochemistry in the diagnosis of bone tumors. J Med Sci Res 2014; 2(2):84-90. DOI:  http://dx.doi.org/10.17727/JMSR.2014/2-016  

Copyright: © 2014 Sailaja M et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Immunohistochemistry (IHC) plays an important role in the diagnosis of some bone tumors, especially in the differential diagnosis of primary from metastatic non-osseous tumors and in the categorization of small-round-blue-cell tumors. Use of two positive and two negative markers is ideal to improve the specificity. Choice of markers depends upon what tumors are logically within differential diagnosis after seeing the morphology, in correlation with clinical and radiological details provided to the pathologist. Our present article reviews immunomarkers used in bone tumors and their diagnostic significance.