2018 December
Volume : 6 Issue : 4

Tumors and tumor like lesions of the patella - Pictorial essay

Subbarao Kakarla

Pdf Page Numbers :- 103-116

Subbarao Kakarla1,*


1KIMS Foundation and Research Centre, Minister Road, Secunderabad - 500003, Telangana, India


*Corresponding author: Prof. Kakarla Subbarao, MS, D.Sc. (HON), FRCR, FACR, FICP, FSASMA, FCCP, FICR, FCGP, Chairman, KIMS Foundation and Research Centre, Minister Road, Secunderabad - 500003, Telangana, India. Email:


Received 12 July 2018; Revised 24 August 2018; Accepted 5 September 2018; Published 11 September 2018


Citation: Kakarla S. Tumors and tumor like lesions of the patella - Pictorial essay. J Med Sci Res. 2018; 6(4):103-116. DOI:


Copyright: © 2018 Kakarla S et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Focal lesions of patella are not infrequent. The patella is an uncommon location for neoplasms. The majority of tumors of the patella are benign, with a significant incidence of chondroblastoma and giant cell tumor. Other lesions include aneurysmal bone cysts, osteoid osteoma and osteoblastoma. In our experience chondroblastoma is the most common benign tumor. Malignant tumors include osteosarcoma, lymphosarcoma and metastasis. Radiological features are similar to the lesions at other sites except periosteal reaction is uncommon. However, tumor like lesions often pose a difficult problem in ruling out a real neoplasm which is important in order to avoid a biopsy. These include developmental, traumatic, infective, metabolic and endocrinal entities. Miscellaneous lesions include Paget disease and degenerative joint disease. Radiologically, it is important to identify the tumor like lesions and to differentiate them from primary neoplasms. Advanced imaging is rarely necessary, but histological confirmation is mandatory.


Keywords: Benign; malignant tumors; patella; tumor like lesions; gout; brown tumor; Paget’s

Full Text


Patella is the largest sesamoid in the quadriceps tendon. Although fractures of the patella are more common, tumors and tumor like lesions are not infrequent. The benign tumors such as chondroblastoma, giant cell tumor, aneurysmal bone cyst, osteoid osteoma and osteoblastoma show characteristic radiological patterns [1-4]. Tumor like lesions which include developmental dorsal defect of the patella, post traumatic lesions, osteomyelitis, gout, metabolic and endocrinal disorders reflect on patella [5-9]. Miscellaneous lesions like Paget also should be considered in differential diagnosis. There are very few publications in the radiological literature focusing on patellar lesions. Benign tumors of patella are categorised in Table 1.  


Table 1: Benign tumors of patella.

  • Chondroblastoma
  • Giant cell tumor
  • Aneurysmal bone cyst
  • Osteoid osteoma
  • Osteoblastoma


Radiological characteristics and discussion


It is a rare benign cartilaginous tumor that arises primarily in the epiphysis/ apophysis of a long bone and may extend to the metaphysis. It may occur in small bones of the foot and rarely in the patella. The average age is 1st and 2nd decades with no particular preference to the sex. Radiological characteristics include an expanding lytic lesion arising from the centre of the patella with a lobulated outline with a sclerotic margin [10-12]. No soft tissue swelling is present, unless there is a pathological fracture. It may involve part of the patella or may extend to the entire bone. Punctate type of calcifications may be seen in 1/3rd of the patients. MRI shows variable findings (Figure 1).


Figure 1: Chondroblastoma: (a) lateral knee, (b, c) MRI, (d) AP view, (e) Lateral, (f) skyline view, (g) MRI.


Giant cell tumor

This tumor generally occurs at the ends of the long bones extending to the articular margin. The average age is between 3rd and 4th decades. Slight predominance is noted in females. Radiologically, an expanding lytic lesion is noted with soap-bubble appearance (Figure 2a, b, c). The lesion extends to the articular margin. Mineralisation of the matrix is absent [13-15]. On occasion, the lytic lesions may be completely lucent without any bony trabiculae (Figure 2d, e) simulating aneurysmal bone cyst. On occasion, an aneurysmal bone cyst may be associated, in which instance fluid-fluid levels are noted on MRI.


Figure 2: Giant cell tumor of the patella; (a, b) plain films, (c) MRI. (d, e ) 25 F- Giant cell tumor-plain films.


Aneurysmal bone cyst (ABC)

This is a benign cystic lesion with multiple blood filled spaces. The matrix is not mineralised. It can be primary or secondary. The etiology is unknown, although in many cases a history of trauma is elicited. The age group extends from 1st to 4th decades. Secondary ABC is associated with many tumors including giant cell tumor, chondroblastoma, osteoblastoma and telangiectatic osteosarcoma. Radiologically, it is an expanding lytic lesion with few trabeculae. It may be segmental or may occupy the entire bone [16, 17]. MRI shows fluid-fluid levels (Figure 3a, b, c).


Figure 3: Aneurysmal bone cyst; (a) lateral film, (b, c) MRI.


Osteoid osteoma

It is a benign osseous tumor generally occurring in the younger age group. It may be intracortical, periosteal, trabecular or subarticular. Radiologically, a sclerotic central nidus is noted in a surrounding lucent area (Figure 4). Reactive new bone is often present [18, 19].


Figure 4: Osteoid Osteoma of patella.



It is a benign bone producing tumor similar to osteoid osteoma. However, the central nidus is more than 2cms in diameter and hence called giant osteoid osteoma. The morphology is variable with sclerotic areas in and around the lesion. It is very rare in the patella [20].


Primary malignant tumors: Osteosarcoma, Lymphosarcoma.

Secondary: Metastasis.



Morphologically and histologically several types have been described. In patella the most common morphological type is osteoblastic osteosarcoma. It is commonly encountered between the ages of 2nd and 3rd decades. There is no sex preference. In the long bones the metaphysis is primary site. Extensive neoplastic bone is noted in the form of clouds in the matrix extending in to soft tissues (Figure 5a). Both lytic and sclerotic lesions may be noted at the same site (Figure 5b, c, d). Periosteal reaction is not observed in the patella [21].


Figure 5: (a) Osteosarcoma of patella (note the cloud like new bone formation). (b,c,d) Osteosarcoma of the patella.


Lymphoma may be Hodgkin’s or non-Hodgkin’s. Primary lymphoma of the bone is quite rare and involvement of the patella is rarer. It is more common in males. Osteolytic lesions are more common than mixed or purely sclerotic lesion. Radiologically, no definite characteristics are noted in any given situation. A mixed lytic and sclerotic lesion with a soft tissue swelling in a young person should suggest lymphosarcoma [22] (Figure 6).


Figure 6: Lymphosarcoma in a 15-year-old boy.


Solitary metastasis to patella is very rare. However, case reports have been published about metastasis arising from primary carcinoma of the breast and bronchus involving the patella. Metastatic lesions presented in order of frequency of primary tumors include breast, lung, prostate and kidney (Figure 7a, b). Radiologically while lytic, mixed and sclerotic lesions are common in carcinoma from breast, lung and kidney, sclerotic metastasis are more common in the carcinoma of the prostate. However, any primary in the body can metastasise to the bone [23]. In a solitary metastasis to the patella, it is difficult radiologically to diagnose without knowing the primary site of the lesion.


Figure 7: (a, b) Lytic metastasis from carcinoma breast


Tumor like lesions

  • Developmental
  • Traumatic
  • Infective
  • Osteonecrosis
  • Metabolic – Gout, Hyperparathyroidism
  • Miscellaneous


In developmental abnormalities of the patella, bipartite and tripartite patella are relatively common. Bipartite patella is found in 2% of people. Bilateral involvement is noted in around 4% of people. Some authors consider that bipartite patella is probably traumatic [24]. Radiologically, these are located in the supero medial margin of the patella (Figure 8a, b).


Figure 8: (a, b) Bipartite & tripartite patella.


The dorsal defect of the patella (DDP) is a benign lesion with specific radiographic features. The characteristic lesion is round and lytic, with well-defined margins (Figure 9a, b, c). It is located in the superolateral aspect of the patella adjacent to the subchondral bone [25, 26]. Arthrography reveals intact cartilage. DD – Osteo chondritis dissecans.


Figure 9: Dorsal defect of patella; (a, b) plain films, (c) MRI.


Osteochondritis dissecans

Most probable etiology includes direct or indirect trauma. Infection does not play a role. It is more common in medial femoral condyle, talus and capitellum of humerus. Radiologically, a lytic defect is noted in the articular margin of the patella with a loose ossified fragment [27] (Figure 10). MRI shows the relationship of the subcondral fragment to the underlying host bone and hyaline cartilage.


Figure 10: Osteo chondritis dissecans of patella.


Infections of the patella Pyogenic osteomyelitis primarily involving the patella is rare. In septic arthritis of the knee, the patella may be involved and does not show any specific radiological characteristics (Figure 11a). Aspiration & culture of the synovial fluid may show pyogenic organisms such as staphyloccal and other bacteria. Pyogenic osteomyelitis with brodie’s abscess is also relatively uncommon [28]. Radiologically, a circular/oval lytic area surrounded by reactive sclerosis is noted. MRI shows the penumbra effect (Figure 11b-f).


Figure 11: (a) Septic arthritis showing synovial effusion, (b-f) Brodie’s abscess in conventional, (d, e, f) MRI & CT films.


Tuberculosis of the patella

Osteoarticular tuberculosis of the knee is not rare [29]. In skeletal tuberculosis, tuberculosis of the knee is encountered in about 10% of the time. Patella may be involved in this process. Radiologically, peripheral erosions of the articular margins with para-articular osteoporosis and synovial thickening characterise tubersulsois. The patella may show extensive erosions. Reactive bone is not a feature of tubercular arthritis (Figure 12a, b). However, isolated patellar tuberculosis is quite rare [30]. Radiologically, it may resemble Brodie’s abscess with a lytic defect surrounded by sclerosis. MRI shows penumbra effect and may also show caseation with necrosis extending to the joint (Figure 12c, d, e).


Figure 12: (a, b) Tuberculous arthritis of knee involving patella. (c, d, e) TB abscess of patella; plain and MRI.


Osteonecrosis of the patella

Osteonecrosis of the patella can occur in two locations of the patella, one superiorly and the second inferiorly. Several controversies exist regarding the etiology. A distinction is made between osteochondritis of the centre of patella or the primary nucleus (Kohler disease) and osteochondritis of the secondary ossification centre at the lower pole (Sinding-Larsen-Johansson disease - SLJ). Kohler disease can also refer to navicular avascular necrosis. The diagnosis of osteochondritis of the patella can only be made when the radiographic finding is definitely accompanied by clinical symptoms. It may be bilateral [31-33]. Osteonecrosis may be traumatic or iatrogenic due to steroid or radiation therapy. Radiologically, Kohler’s disease shows increased density with fragmentation (Figure 13a), whereas in SLJ, the inferior pole of the patella is involved with fragmentation (Figure 13b, c).


Figure 13: (a) Osteonecrosis of patella-Kohler’s disease. (b, c) Sinding-Larsen-Johansson disease.


Gout of patella

Gout is an inflammatory arthropathy caused by long-standing hyperuricemia. The first meta-tarsophalangeal joint is the most commonly involved joint, although gout is often polyarticular. Involvement of the knee is not uncommon, but involvement of the patella is rare [34, 35]. Isolated involvement of patella in gout is extremely unusual. Radiologically, multiple lytic areas are noted with sclerotic margin, involvement of the knee joint renders a clue to the diagnosis (Figure 14).


Figure 14: (a, b, c) Gout of knee joint and patella.


Brown tumors of hyperparathyroidism involving the patella

Brown tumors which are localised lytic areas in bone with areas of fibroblasts and giant cells superimposed by hemorrhage. These are encountered commonly in long bones and jaws. These brown tumors are seen in both primary and secondary hyperparathyroidism. However, brown tumors involving the patella are rare [36]. Radiologically, marked osteoporosis and cortically oriented lytic lesions are noted (Figure 15). Clinical and laboratory data confirm the presence of hyperparathyroidism.


Figure 15: 34-years-old-female, brown tumor of patella in hyperparathyroidism.


Paget disease of patella

Paget disease of the skeleton is occasionally observed in India. Radiologically, 3 forms are noted: 1. Osteolytic, 2. Osteoblastic, 3. Mixed. The bones involved often include skull, spine, pelvis and long bones. Patellar involvement is quite rare [37, 38]. The appearances as indicated may be sclerotic, lytic or mixed type of lesions. Bones involved in Pagets are larger than usual and the process may extend to the articular margin (Figure 16).


Figure 16: Paget patella (note the enlargement and mixed lytic & sclerotic lesion).


Quadriceps tendinopathy & patella

The quadriceps tendon is attached to the patella. In degenerative arthritis as well as in diffuse skeletal hyperostosis, multiple osteophytes are noted in the superior & anterior surface of the patella. Radiologically, this can resemble a dentate structure and hence called ‘Tooth sign’ [39]. Sometimes it may simulate whiskers and hence called ‘whiskering’. These are best demonstrated in the skyline view of the patella (Figure 17).


Figure 17: (a) Tooth sign, (b) Whiskering enthesophytes- DISH.



The patella is an uncommon location for neoplasms. The majority of tumors of the patella are benign, with a significant incidence of giant cell tumor and chondroblastoma. In our experience chondroblastoma seems to be more common. Radiological features are similar to the lesions at other sites. Tumor like lesions including developmental, infective, metabolic and of miscellaneous etiology are included in the differential diagnosis describing the radiological findings with the help of illustrations.



NIMS, KIMS, and KREST Museum, Hyderabad.


Conflicts of interest

Author declares no conflicts of interest.



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