Association of estrogen and progesterone with cancer of the uterine cervix in women infected with high-risk human papillomavirus

Baskaran K, Kumar PK, Santha K, Sivakamasundari I

Pdf Page Numbers :- 74-79

Krishnan Baskaran^1,*, Kranthi Kumar P², Santha K¹ and Inmozhi Sivakamasundari¹

¹Department of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar, Tamil Nadu, India

²Department of Genetics, Narayana Medical College & Hospital, Nellore, Andhra Pradesh, India

*Corresponding author: Dr. Krishnan Baskaran, Department of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar, Tamil Nadu, India. Email: drjashmi@gmail.com

Received 30 March 2018; Revised 21 May 2018; Accepted 06 June 2018; Published 12 June 2018

Citation: Baskaran K, Kumar PK, Santha K, Sivakamasundari I. Association of estrogen and progesterone with cancer of the uterine cervix in women infected with high-risk human papillomavirus. J Med Sci Res. 2018; 6(3):74-79. DOI: http://dx.doi.org/10.17727/JMSR.2018/6-13

Copyright: © 2018 Baskaran K et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: High-risk human papillomavirus (HR-HPV) infection is essential for the development of dysplasia and cervical cancer. Steroid hormones are implicated as risk factors for cervical carcinogenesis. Thus the aim of the present study is to investigate the association of serum levels of estrogen and progesterone with cervical cancer in HR-HPV infected women.

Methods and materials: The present study consisted of 103 subjects infected with HR-HPV from low-grade squamous intraepithelial lesion (LSIL) to cervical cancer. They included 37 premenopausal women (luteal phase) and 43 postmenopausal women as cancer cases (high-grade squamous intraepithelial lesion and cervical cancer). Twelve women with LSIL for premenopausal and 11 women with LSIL for postmenopausal were chosen as controls. The concentration of estradiol and progesterone were estimated using enzyme linked immuno sorbent assay kit. The prevalence of HPV infection was expressed as percentage of HPV positives. The data for estradiol and progesterone were expressed as mean ± SD.

Results: The serum levels of estradiol were not significantly altered in premenopausal and postmenopausal cases (p>0.05). However, the serum levels of progesterone were significantly increased in premenopausal cases as compared to premenopausal controls (p<0.025). The serum levels of progesterone were not significantly altered in postmenopausal cases (p>0.05). The ratio of estradiol to progesterone was significantly decreased in premenopausal cases (p<0.001) where as it was not significant in postmenopausal cases (p>0.05).

Conclusion: A significantly elevated levels of progesterone is associated with cervical cancer in premenopausal women infected with HR-HPV.

Keywords: Cervical dysplasia; cervical cancer; steroid hormones; estrogen; progesterone