Biochemical evaluation of thyroid hormone level in infertile women: A case control study

Borgaonkar K, Patil R

Pdf Page Numbers :- 68-71

Kavindra Borgaonkar^1,* and Ranjit Patil²

¹Department of Biochemistry, Govt. Medical College, Latur, Maharashtra 413512, India

²Department of Biochemistry, S.S.R. Medical College, Belle Rive, Mauritius

*Corresponding author: Dr. Kavindra Borgaonkar, Department of Biochemistry, Govt. Medical College, Latur, Maharashtra 413512, India, Email: kavindra.borgaonkar.21@gmail.com

Received 15 September 2023; Revised 25 November 2023; Accepted 4 December 2023; Published 14 December 2023

Citation: Borgaonkar K, Patil R. Biochemical evaluation of thyroid hormone level in infertile women: A case control study. J Med Sci Res. 2024; 12(1):68-71. DOI: http://dx.doi.org/10.17727/JMSR.2024/12-12

Copyright: © 2024 Borgaonkar K et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Introduction: Infertility in women is an important health problem which imposes psychological stress and affects the wellbeing of couples. Thyroid disorders is the most frequently encountered endocrine problem among the women in the age reproductive and it can lead to infertility and miscarriage. The objective of the study was to evaluate the thyroid hormone level in infertile women and compared to the healthy controls.

Materials and methods: The study was conducted on 50 infertile women (cases) and 50 fertile healthy women (controls). Thyroid stimulating hormones (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and Anti-thyroid peroxidase (Anti-TPO) levels were estimated and compared between the cases and controls.

Results: The mean TSH level was significantly higher in infertile women (cases) as compared controls (6.76±0.87 vs 2.54±0.12mIU/L; p=0.002).The prevalence of hypothyroidism among the infertile women in the present study was 28%. The anti-TPO antibody level was significantly higher was in infertile women as compared to controls (4.87±0.8 vs 2.32±0.05 IU/ml; p=0.000). In addition the number of positive Anti-TPO antibody cases was higher in infertile women as compared to controls (24% vs 4%; p=0.02).

Conclusion: Therefore, women planning for pregnancy and infertile women must be evaluated for thyroid profile and if there are any abnormalities they should undergo proper treatment for better pregnancy outcome.

Keywords: infertility; women; thyroid profiles; thyroid stimulating hormone; hypothyroidism