Clinicopathological spectrum of patients with lupus nephritis in a tertiary care hospital

Harika Venishetty, Sujatha Poduval K, Satish Rao I, Reddy VS

Pdf Page Numbers :- 36-42

Harika Venishetty^1,*, Sujatha Poduval K¹, Satish Rao I¹, and Reddy VS²

¹Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

²Department of Nephrology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

*Corresponding author: Dr. Sujatha Poduval K, Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Email: radhakishore.veni@gmail.com

Received 21 January 2019; Revised 7 March 2019; Accepted 18 March 2019; Published 26 March 2019

Citation: Venishetty H, Poduval KS, Satishrao I, Reddy VS. Clinicopathological spectrum of patients with lupus nephritis in a tertiary care hospital. J Med Sci Res. 2019; 7(2):36-42. DOI: http://dx.doi.org/10.17727/JMSR.2019/7-8

Copyright: © 2019 Venishetty H et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Aim: The aim is to determine the distribution of different classes of lupus nephritis based on renal biopsy and to correlate it with serum creatinine and proteinuria.

Objectives: To study the prevalence of different classes of systemic lupus erythematosus (SLE) using the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification in our facility, and to determine the correlation between the histopathological features of different classes of lupus nephritis and the clinical and laboratory parameters.

Material and methods: Renal biopsy specimens with a clinical diagnosis of SLE by ARA criteria in a period of 3 years received in the laboratory were included in the study and were classified according ISN/RPS 2003 classification. The clinical and laboratory data were obtained from patient files.

Results: Out of 40 patients, 35 (88%) were females and 5 (12%) were male patients. Mean age was 32.7±10.7 years. Majority of patients belong to class IV (53%) followed by class III (22%).

Conclusion: In this study the commonest class of International Society of Nephrology (ISN)/Renal Pathology Society (RPS) classification is class IV and there is significant correlation between 24 h proteinuria with ISN/RPS classes.

Keywords: Systemic lupus erythematosus; lupus nephritis; nephritic syndrome; autoimmune