Polycystic ovarian syndrome and microbiome: Implications for women’s health

Patel N, Singh D, Lokary V, Shaker IA

Pdf Page Numbers :- 47-56

Neeti Patel¹, Divya Singh², Vijaya Lokary³ and Ivvala Anand Shaker^4,*

¹Department of Biochemistry, Kiran Medical College, Vadod, Surat, Gujarat 394520, India

²Department of Biochemistry, Dr. Kiran C. Patel Medical College and Research Institute, Bharuch, Gujarat-392001, India

³Department of Biochemistry, Mamata Medical College and General Hospital, Khammam, Telangana 507002, India

⁴Department of Biochemistry, Parul Institute of Medical Sciences and Research, Vadodara, Gujarat 391760, India

*Corresponding author: Dr. Ivvala Anand Shaker, Department of Biochemistry, Parul Institute of Medical Sciences and Research, Vadodara, Gujarat 391760, India. Email: ivvala.shaker@paruluniversity.ac.in

Received 10 October 2022; Revised 30 November 2022; Accepted 9 December 2022; Published 19 December 2022

Citation: Patel N, Singh D, Lokary V, Shaker IA. Polycystic ovarian syndrome and microbiome: Implications for women’s health. J Med Sci Res. 2023; 11(1):47-56. DOI: http://dx.doi.org/10.17727/JMSR.2023/11-10

Copyright: © 2023 Patel N et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

The endocrine condition known as polycystic ovarian syndrome (PCOS) is complicated and diverse. It impacts between 4 to 20 % of women of reproductive age and is linked to a significant risk of infertility, obesity, and insulin resistance. The aetiology of PCOS remains unclear and can be multifactorial, including genetic, neuroendocrine, and metabolic causes. Recent studies in humans have shown an association between changes in the gut and vaginal microbiome and the metabolic and clinical parameters of PCOS. The aim of this review was to understand the relationship between PCOS and the microbiome, including any potential underlying mechanisms, and to look at potential therapeutic strategies to improve the therapeutic approach for patients. As a result, a hypothesis is postulated that changes in the microbiota contribute to the development of PCOS and explored the therapeutic opportunities which include probiotics, prebiotics, synbiotics, fecal microbiota transplantation and IL-22.

Keywords: polycystic ovarian syndrome; PCOS; microbiome; insulin resistance; therapeutics