Post-operative cognitive dysfunction – A brief review

Jayashree Patki, Sriram Ravinutala

Pdf Page Numbers :- 31-34

 Jayashree Patki^1,* and Sriram Ravinutala¹

¹Department of Anaesthesiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

*Corresponding author: Dr. Jayashree Patki, MBBS, MD, PGDHHM, Department of Anaesthesiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Email- pjayashree311@gmail.com

Received 17 October 2015; Revised 5 December 2015; Accepted 17 December 2015; Published 26 December 2015

Citation: Patki J, Ravinutala S. Post-operative cognitive dysfunction – A brief review. J Med Sci Res. 2016; 4(1):31-34. DOI: http://dx.doi.org/10.17727/JMSR.2016/4-010

Copyright: © 2016 Patki J, et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Postoperative cognitive dysfunction (POCD) can be referred to as a mild but possibly long-lasting altered intellectual function occurring after surgery, which is more common in old age. It may last from a few hours to some months or may be permanent. Up to half of patients, young and old, have POCD within the first week after surgery. Three months later, 10 to 15 percent of patients still have POCD. It's still unknown whether POCD results from some neurotoxic effect of anesthetic agents, or it simply reflects a preexisting cognitive (intellectual) problem in older adults. It has also been suggested that cognitive after-effects of surgery may result from an inflammatory process. The nature of the relationship is unclear; as multiple factors are likely involved. As the exact reasons are still not known, further research is needed to identify the patients and procedures at highest risk of POCD, and what steps can be taken to reduce that risk. Anesthesiologists should play a more active role in screening for reducing cognitive dysfunction before surgery.

Keywords: Cognitive dysfunction; general anesthesia; post-operative; opioids; mini mental state examination