Recent advances of nanoparticles in cancer therapy and diagnosis

Srinivasa rao B, Kanaka Bhushanam, Undurti N Das, Prasad TNVKV, Kakarla Subbarao

Pdf Page Numbers :- 95-102

Srinivasa rao B¹, Kanaka Bhushanam¹, Undurti N Das^1,2, Prasad TNVKV³, Kakarla Subbarao¹

¹KIMS Foundation and Research Centre, Minister Road, Secunderabad - 500003, AP, India

²UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA

^₃Institute of Frontier Technology, Regional Agricultural Research Station, Acharya N. G. Ranga Agricultural University, Tirupathi-517502, India

*Corresponding author: Srinivasa Rao B, M.Sc., Ph.D., KIMS Foundation and Research Centre, Minister Road, Secunderabad - 500003, AP, India, Email: srinumicros@yahoo.com

Received 10 May 2013; Accepted 15 June 2013

Citation: Srinivasarao B, Kanakabhushanam GVVS, Das UN, Prasad TNVKV, Kakarla S. Recent advances of nanoparticles in cancer therapy and diagnosis. J Med Sci Res 2013; 1(2): 95-102. http://dx.doi.org/10.17727/JMSR.2013/1-017

Copyright: © 2013 Srinivasa rao B et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PDF

Abstract

Recent advances in nanotechnology may offer new hope for significant improvement in the success of cancer treatment, especially in preventing tumor growth and progression. Having grown exponentially, the focus of nanotechnology has been on engineering diversified novel applications that even go beyond therapeutic activity; nanotechnology also offers the ability to detect diseases, such as cancer, much earlier than ever imaginable. Nanoparticles with enhanced surface properties are able to diffuse with greater ease inside the tumor cells delivering a high amount of drug selectively to tumor cells with significant reduced toxicity. The association of chemotherapeutic agents with nanoparticles offers improvement in the solubility and stability of antitumor agents, avoidance of drug degradation, and reductions in therapeutic dose and toxicity, increasing drug levels in tumor tissue and decreasing them in healthy tissue. In this review, we discuss the current state of research on applications of nanoparticles (NPs) for cancer therapy, diagnosis and also advance of nanoparticles.

Keywords: Nanotechnology; Nanoparticles; Liposome; Micelles; Quantum dot; Gold nanoparticles, Magnetic nanoparticles; Carbon nanotubes; Dendrimers; Cancer therapy; Cancer biomarkers