Serum gamma glutamyl transferase levels in metabolic syndrome in obese south Indian population

Fernando ML, Babu SV, Silambanan S

Pdf Page Numbers :- 158-162

Mario Leesha Fernando^1,*, Vinod Babu S² and Santhi Silambanan³

¹Department of Biochemistry, Bhaarath Medical College and Hospital (BIHER), Chennai-600073, Tamil Nadu, India

²Department of Biochemistry, Saveetha Medical College and Hospital, Chennai-602105, Tamil Nadu, India

³Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai-600116, Tamil Nadu, India

*Corresponding author: Mario Leesha Fernando, Associate Professor, Department of Biochemistry, Bhaarath Medical College and Hospital (BIHER), Chennai-600073, Tamil Nadu, India. Email: dr.leesha@gmail.com

Received 2 March 2023; Revised 24 May 2023; Accepted 5 June 2023; Published 16 June 2023

Citation: Fernando ML, Babu SV, Silambanan S. Serum gamma glutamyl transferase levels in metabolic syndrome in obese south Indian population. J Med Sci Res. 2023; 11(3):158-162. DOI: http://dx.doi.org/10.17727/JMSR.2023/11-30

Copyright: © 2023 Fernando ML et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PDF

Abstract

Background: Increased waist circumference in metabolic syndrome (MS), which reflects central obesity is associated with an increased risk of type 2 diabetes, dyslipidemia, hypertension and coronary vascular disease. Generation of free radicals in central obesity depletes intracellular glutathione, thereby induces release of gamma glutamyl transferase (GGT) into circulation. Elevated GGT levels could be a marker of high oxidative stress which is known to be associated with central obesity and metabolic syndrome. Hence the aim of this study was to determine the association of GGT levels with components of metabolic syndrome in obese South Indian population.

Materials and methods: In this case control study conducted at Master Health Check (MHC) Department, Sri Ramachandra Medical College, study population included 60 obese subjects with metabolic syndrome (cases) and 60 non obese subjects (controls) of South Indian population who were non-smokers and non-alcoholics, between the ages of 30-50 years. Components of metabolic syndrome such as waist circumference, blood pressure, fasting plasma glucose, lipid profiles and GGT measured in both the groups. Data between cases and controls compared with unpaired student t-test. Pearson’s correlation was performed to find the association of GGT levels with other variables in Metabolic syndrome.

Results: Serum GGT levels were significantly higher in metabolic syndrome patients (cases) than controls with p < 0.0001. High levels of serum GGT were also associated with increase in BP and atherogenic lipid levels and ratios.

Conclusion: Elevated serum GGT levels were significantly associated with components of metabolic syndrome in obese South Indian population.

Keywords: metabolic syndrome; syndrome X; obesity; gamma glutamyl transferase; oxidative stress