To evaluate the influence of inhaled bronchodilator therapy on spirometric test variables in obese and non-obese asthmatics

Latha Sarma, Nandan Putti, Avinash Chaskar, Kapil Alias Mohit Chilana, Asmath Qureshi

Pdf Page Numbers :- 166-171

Latha Sarma^1,*, Nandan Putti^1,*, Avinash Chaskar¹, Kapil Alias Mohit Chilana¹ and Asmath Qureshi¹

¹Department of Pulmonology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India.

*Corresponding authors: Dr. Latha Sarma, Critical respiratory & Sleep specialist, Department of Pulmonology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India, Email: dr.lathasarma@gmail.com and Nandan Putti, Department of Pulmonology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Tel.:+919014036776; Email: naddyn7@gmail.com

Received 20 June 2015; Revised 3 September 2015; Accepted 10 September 2015; Published 18 September 2015

Citation: Latha Sarma, Nandan Putti, Avinash Chaskar, Mohit Chilana KA, Asmath Qureshi. To evaluate the influence of inhaled bronchodilator therapy on spirometric test variables in obese and non-obese asthmatics. J Med Sci Res. 2015; 3(4):166-171. DOI: http://dx.doi.org/10.17727/JMSR.2015/3-032

Copyright: © 2015 Latha Sarma, et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

In India, the prevalence of overweight individuals is reported to be between 20-40% in various studies, with over 5-10% being obese. Obesity acts as a risk factor for asthma through various mechanisms and it also reduces the spirometric variables as well as total lung capacity and functional residual capacity. Forced expiratory volume in one second (FEV1) was done on 100 patients in tertiary care hospital using RMS Helios 401 electronic spirometer, by Recorders and Medicare Systems Pvt. Ltd. All the statistical analysis was done using SPSS, Ver. 17.0, (IBM, Chicago, Illinois and student unpaired T-test and analysis of variance (ANOVA) test was used for estimating results. 59 were males and 41were females, of the 59 males, 29 were obese and 30 were non-obese and of the 41 females 20 were obese and 21 were non-obese. There was highly significant difference found in the spirometric variables in obese and non-obese asthmatics. There is significant amount of reversibility (% change) after inhalation of short acting beta-2 agonist in non-obese group as compared with obese group with mean percentage change in non-obese group being 16.20% and obese group 13.58%. p value 0.002(p<0.05). The amount of reversibility (mean % change) was found to be more for controlled asthmatic groups (16.88%) as compared with partly controlled asthmatics (14.84%) and uncontrolled asthmatic groups(12.78%) p value 0.001(p<0.05). To conclude, it can be said that age does not have any significant influence on the levels of asthma control in both obese and non-obese asthmatics. Obesity has a significant influence on various spirometric variables.

Keywords: asthma; obese; non-obese; spirometry values; reversibility; cross sectional study