Importance of bone marrow biopsy in assessment of treatment response in a case of acute myeloid leukemia

Kasula S, Poduval SK, Mounika B

Pdf Page Numbers :- 180-182

Siddartha Kasula^1,*, Sujatha K Poduval¹, and Boppana Mounika²

¹Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

²Department of Medical Oncology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India.

*Corresponding author: Siddartha Kasula, Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Email: dr.siddartha1987@gmail.com

Received 29 July 2020; Revised 16 August 2020; Accepted 25 August 2020; Published 5 September 2020

Citation: Kasula S, Poduval SK, Mounika B. Importance of bone marrow biopsy in assessment of treatment response in a case of acute myeloid leukemia. J Med Sci Res. 2020; 8(4):180-182. DOI: http://dx.doi.org/10.17727/JMSR.2020/8-24

Copyright: © 2020 Kasula S et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Chemotherapy response in acute leukemias is usually assessed by bone marrow examination along with ancillary studies like flowcytometry/ polymerase chain reaction for minimal residual disease (MRD). Decisions regarding post induction chemotherapy are based on bone marrow remission status. Bone marrow aspiration alone is asked by many oncologists/ hematologists for assessing the remission status. Rarely pockets/ clusters of blasts may not be picked up in the aspiration and the same for MRD also. Hence, bone marrow biopsy is necessary for those clusters/ pockets of blasts. In this case report we are highlighting the importance of both aspiration and biopsy for assessing the treatment response.

Keywords: bone marrow biopsy; remission; treatment response; acute leukemia