Outcomes of early and interval laparoscopic cholecystectomy for acute cholecystitis at a teaching hospital in Kerala: A prospective observational comparative study

Thomas J, Oommen AN, Mathew J, Abhijith V, Joy RR

Pdf Page Numbers :- 66-71

John Thomas¹, Ashok Nınan Oommen^1,* , John Mathew¹, Abhijith V¹ and Rejana R Joy¹

¹Dept of General Surgery, Jubilee Mission Medical College & Research Institute, Thrissur, Kerala – 680005, India

*Corresponding author: Dr. Ashok Nınan Oommen MS, Professor & Head, Dept of General Surgery, Jubilee Mission Hospital, Jubilee Mission Medical College & research Institute, Thrissur – 680005, India. Email: ashokno@yahoo.com

Received 5 November 2022; Revised 21 February 2023; Accepted 2 March 2023; Published 9 March 2023

Citation: Thomas J, Oommen AN, Mathew J, Abhijith V, Joy RR. Outcomes of early and interval laparoscopic cholecystectomy for acute cholecystitis at a teaching hospital in Kerala: A prospective observational comparative study. J Med Sci Res. 2023; 11(2):66-71. DOI: http://dx.doi.org/10.17727/JMSR.2023/11-13

Copyright: © 2023 Thomas J et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Timing of laparoscopic cholecystectomy, a widely used treatment modality for acute cholecystitis remains controversial. This prospective observational comparative study investigated patient outcomes for early (ELC) and interval laparoscopic cholecystectomy (ILC) in patients with acute cholecystitis admitted to the General Surgery Department at a tertiary care centre in Thrissur, Kerala, between December 2018 and June 2020. Of 67 patients, 34 were assigned to ELC and 33 to ILC groups and followed up for 2 weeks post-surgery. Patient characteristics, clinical features, investigations, intra operative details and post operative outcomes were tabulated. Comparison of age was statistically analyzed using student’s ‘t’ test, demographics and morbidity data using Fisher’s exact test/ Chi-square test and length of hospital stay using Mann Whitney U test. Mean age was significantly higher in the ILC group. 66% of study participants were females with a higher proportion of females observed in the ILC group. Post-surgical complications were not significantly higher in ELC group compared to ILC group. Total length of hospital stay was significantly longer in the ILC group than in ELC group (10.2 ±4.5 vs. 7.1 ±3.0) days, p value: 0.001). Duration of hospital stay for the laparoscopic cholecystectomy procedure taken separately, was longer in ELC group comparatively, 7 ±3.01 versus 4 ±-2.38, (p value: <0.001). There was no mortality. It was observed in the present study that ELC is preferable to ILC for acute cholecystitis with added benefit of shorter hospital stay. Further large randomized trials would be valuable to make recommendations for future management.

Keywords: acute cholecystitis; laparoscopic cholecystectomy; hospital stay; conversion rate