Association of vitamin D and inflammatory biomarkers with newly diagnosed cases of hypothyroidism- A case-control study

Ahmad N, Iqbal S, Ahmad M, Farooque I, Khatoon T, Gupta A, Ahmad T

Pdf Page Numbers :- 153-157

Naved Ahmad¹, Shahid Iqbal², Mushir Ahmad³, Ibrahim Farooque⁴, Tayyaba Khatoon⁵, Akash Gupta⁶ and Tausif Ahmad⁷

¹Department of Biochemistry, FH Medical College and Hospital, Agra, Uttar Pradesh 283204, India

²Department of Biochemistry, Integral Institute of Medical Sciences and Research Integral University, Lucknow, Uttar Pradesh 226026, India

³Department of Biochemistry, Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh 244236, India

⁴Department of Physiology, Maharshi Vishwamitra Autonomous State Medical College, Ghazipur, Uttar Pradesh 233001, India

⁵Department of Ilmul Amraz, Ajmal Khan Tibbiya College, AMU, Aligarh, Uttar Pradesh 202002, India

⁶Department of Biochemistry, NCRIMS Nalpur, Meerut, Uttar Pradesh,245206, India

⁷Director-Regulatory Affairs, MG Biological Pvt Ltd New Delhi 110020, India

*Corresponding author: Dr. Mushir Ahmad, Professor, Department of Biochemistry, Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh 244236, India. Email: drnavedahmad@gmail.com

Received 10 January 2024; Revised 28 February 2024; Accepted 11 March 2024; Published 19 March 2024

Citation: Ahmad N, Iqbal S, Ahmad M, Farooque I, Khatoon T, Gupta A, Ahmad T. Association of vitamin D and inflammatory biomarkers with newly diagnosed cases of hypothyroidism- A case-control study. J Med Sci Res. 2024; 12(2):153-157. DOI: http://dx.doi.org/10.17727/JMSR.2024/12-29

Copyright: © 2024 Ahmad N et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: Deranged thyroid hormones and TSH induces the release of inflammatory biomarkers and recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases, but there is little documented evidence available about the association of vitamin D and inflammatory biomarkers. So, this study was planned to investigate the relationship between vitamin D and inflammatory biomarkers.

Materials and Methods: This case-control study was carried out among 60 study participants (30 cases and 30 controls) in the Department of Biochemistry, F.H Medical College, its associated Hospital from January 2023 to June 2023 The samples were divided in to two groups, cases (hypothyroid patients) and healthy control group. Serum was separated by centrifuging blood at 3000 rpm for 10 mi. Estimation of CRP was done turbidimetric immune assay method. Statistical analysis was done by using the (SPSS) version 20.0. Pearson correlation and Student’s t-test was applied, p-value <0.0001 was taken as significance.

Results: The (mean ±SD) CRP values in the subjects having hypothyroid disorder (cases) were 3.12± 0.79 mg/L and in control was 2.01±0.75 mg/L (p-value <0.0001). The weight was found to be higher in cases. The CRP and IL-6 had an insignificant correlation with the BMI (r=0.06, p=0.74) and (r=0.64, p=0.35) and also insignificant correlation was found in between the CRP and the blood pressure.

Conclusion: This study concludes that CRP and IL-6 levels were significantly higher in hypothyroid patients and insignificant correlation was found between anthropometric measurements of hypothyroid patients and inflammatory biomarkers.

Keywords: vitamin D; CRP; IL-6; hypothyroidism; hypothyroid patients