Orginal Research
2025 March
Volume : 13 Issue : 1


Denovo and uncontrolled stroke risk factors and triggers in a tertiary care hospital

Kaul S, Reddy KN, Deekshitha S, Banavath H, Lolla S, Beevi SS, Verma VK

Pdf Page Numbers :- 1-5

Subhash Kaul1,3, Kasireddy Navneeth Reddy2, Sunkari Deekshitha2, Hasini Banavath2, Sidhartha Lolla2, Syed Sultan Beevi3,* and Vinod Kumar Verma3,*

 

1Department of Neurology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India.

2Department of Pharmacy Practice, Pulla Reddy Institute of Pharmacy, Domadugu, Annaram, Gummadidala, Telangana 502313, India

3KIMS Foundation and Research Centre, Minister Road, Secunderabad-500003, Telangana, India

 

*Corresponding authors: Dr. Syed Sultan Beevi, PhD., and Dr. Vinod Kumar Verma PhD., KIMS Foundation and Research Centre, KIMS Hospitals, Minister Road, Secunderabad 500 003, Telangana, India, Tel.: +91 40 44885056; Fax: +91 40 27840980; Email: drsyedsultan.b@kfrc.co.in; drvinod.v@kfrc.co.in

 

Received 20 September 2024; Revised 28 November 2024; Accepted 6 December 2024; Published 16 December 2024

 

Citation: Kaul S, Reddy KN, Deekshitha S, Banavath H, Lolla S, Beevi SS, Verma VK. Denovo and uncontrolled stroke risk factors and triggers in a tertiary care hospital. J Med Sci Res. 2025; 13(1):1-5. DOI: http://dx.doi.org/10.17727/JMSR.2024/13-1

 

Copyright: © 2025 Kaul S et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract

Background: Stroke, the second leading cause of death and a major cause of disability worldwide, results in over 12.2 million new cases annually. This study investigates the impact of various risk factors and triggers on stroke incidence, with a focus on denovo and uncontrolled hypertension and diabetes mellitus.

Methods: The study cohort consisted of 100 stroke patients. Data on demographic characteristics, lifestyle factors, medical history, and socioeconomic status were collected using a structured questionnaire and medical records

Results: Ischemic stroke was predominant, occurring almost four times more frequently than hemorrhagic strokes. A significant finding was the role of denovo hypertension and diabetes mellitus, in contributing to stroke among patients who were unaware of their health status. Stress, in its various forms—financial, work-related, emotional, and familial—was identified as a major trigger, although many patients reported no discernible triggers. The study also highlighted the knowledge gap in stroke awareness, underscoring the need for targeted educational initiatives.

Conclusion: Our findings emphasize the importance of early detection, effective management of chronic conditions, and stress reduction to mitigate stroke risk. Future studies with larger sample sizes are recommended to further explore these associations and develop comprehensive prevention strategies.

 

Keywords: prevalence; hypertension; diabetes mellitus; stress; ischemic stroke; hemorrhagic stroke

Full Text

Introduction

Stroke, the second leading cause of death and a major cause of disability worldwide [1], results in over 12.2 million new cases annually [2]. The burden is particularly heavy in low and middle-income countries, including India, where stroke is the fourth leading cause of death [3]. In India, the annual incidence ranges from 105 to 152 per 100,000 people [4]. Globally, over 101 million people live with stroke's effects, with women comprising 53% of cases. Each year, 5 million people die from stroke, and another 5 million are left permanently disabled, significantly impacting families and communities [5].

 

The prevalence of stroke has surged in recent years, with a notable 50% increase over the past 17 years, affecting approximately 1 in 4 individuals [6]. This rising incidence can be attributed to an alarming increase in hypertension, hyperlipidemia, diabetes mellitus, and other chronic disorders [7], coupled with lifestyle factors such as physical inactivity, smoking, obesity, inadequate fruit and vegetable consumption, and high sodium intake [8]. While established risk factors such as diabetes mellitus and hypertension are well-documented contributors to stroke [9], there remains a significant challenge in identifying and managing these factors before they lead to severe outcomes. Many individuals may have these risk factors undiagnosed (denovo) and sometimes inadequately treated even after diagnosis.

 

Stroke incidence can also be triggered by a variety of factors, many of which are related to underlying health conditions and lifestyle choices. Extreme physical exertion and emotional stress, such as intense anger or depression, can lead to physiological changes in the body, such as elevated blood pressure, increased heart rate, and heightened levels of stress hormones like cortisol, all of which can contribute to the conditions that predispose someone to a stroke [10]. The challenge in pinpointing physical exertion or emotional stress as direct triggers lies in the multifaceted nature of stroke. A stroke typically occurs due to the cumulative effects of long-standing vascular issues, such as atherosclerosis, hypertension, or other cardiovascular conditions [11]. In the presence of these underlying conditions, extreme physical or emotional stress may act as a catalyst by causing sudden, significant changes in blood pressure or heart rhythm, which can lead to a stroke [10]. Yet, these events do not always result in an immediate stroke, suggesting that additional factors or a critical threshold may need to be crossed for a stroke to occur. Understanding these triggers is crucial for stroke prevention and management, as addressing them can significantly reduce the risk of stroke occurrence.

 

This study sought to provide comprehensive insights into the prevalence of risk factors and triggers, with a particular focus on identifying and understanding both denovo and uncontrolled known risk factors. The findings from this research are expected to significantly enhance the understanding and management of stroke.

 

Methods

Study design and setting

This prospective observational study was conducted in the Department of Neurology at KIMS Hospitals, Secunderabad. The study spanned from August 2023 to November 2023 and included 100 patients who presented with stroke. The study was approved by the Institutional Ethics Committee of KIMS Hospitals (KIMS/EC/BMHR/2023/67-01) and adhered to the Helsinki guidelines for ethical research involving human subjects. All patients were informed about the study's purpose, and written informed consent was obtained from each participant before their inclusion in the study.

 

Study population

Patients aged 16 and above with an acute neurological deficit suggestive of stroke were eligible for inclusion in the study. Those with symptoms unrelated to acute stroke or those who were non-compliant with the study protocol were excluded.

 

Data collection

A structured study questionnaire was developed to capture both clinical and non-clinical information from the patients. The questionnaire included sections on: Demographic information (age, gender, occupation, educational background); Medical history (hypertension, diabetes mellitus, hyperlipidaemia, history of previous strokes or transient ischemic attacks, medication history); Stroke-specific information (time of onset of stroke symptoms, type of stroke-ischemic, haemorrhagic, transient ischemic attacks, presenting symptoms e.g., hemiplegia, speech disturbances, visual impairment); Risk factors (Lifestyle factors such as smoking, alcohol consumption, diet, physical activity, family history of stroke or cardiovascular diseases, comorbid conditions); Triggers (Recent physical or emotional stress, infection, missed medication or fever prior to stroke onset).

 

Upon presentation to the Neurology Department, patients with suspected stroke were evaluated by a neurologist. Eligible patients were then approached by the research team to explain the study details and obtain informed consent. Once consent was obtained, the structured questionnaire was administered through direct interviews and medical record reviews.

 

Patients underwent standard diagnostic procedures, including clinical examinations, and relevant laboratory tests to confirm the diagnosis of stroke and to classify the type of stroke. The collected data were then entered into a secure database for analysis.

 

Data analysis

Descriptive statistics were used to summarize the demographic and clinical characteristics of the study population. Continuous variables were expressed as means and standard deviations, while categorical variables were presented as frequencies and percentages. Comparative analyses were conducted to examine the prevalence of various risk factors and triggers among different subgroups (e.g., ischemic vs. hemorrhagic stroke, male vs. female patients).

 

To ensure data quality, all questionnaires were reviewed for completeness and accuracy. Any discrepancies or missing information were resolved through follow-up interviews with patients or consultations with their medical records.

 

Results

Demographic characteristics

The study cohort consisted of 100 patients, ranging in age from 16 to 90 years (Table 1).

 

Table 1: The age distribution.  

Age range (years)

Number of patients

16 – 30

1

31 - 45

15

46 - 60

32

61 - 75

42

76 – 90

10

 

In terms of gender distribution, 69% of the patients were male and 31% were female, resulting in a male-to-female ratio of 2.22:1.

 

Stroke types and mechanisms

Among the 100 patients in the study, 81% experienced ischemic strokes, while 19% suffered haemorrhagic strokes (Figure 1a). In the haemorrhagic stroke group, the majority of cases were primarily attributed to hypertension. Whereas the mechanisms underlying ischemic stroke were diverse: 40% were due to large artery intracranial atherosclerosis (ICA), 9% to large artery extracranial atherosclerosis (ECA), 14% to lacunar stroke, 9% to cardioembolic stroke, and 18% to unknown mechanisms (Figure 1b). In the study population, 75% were experiencing a stroke for the first time, whereas 25% had a recurrence following a previous stroke (Figure 1c).

 

Figure 1: Stroke types and mechanisms, (a) Distribution of stroke types; (b) Mechanism underlying hemorrhagic and ischemic stroke; (c) Stroke recurrence.

 

Risk factors

The most common risk factors identified in our study population were hypertension and diabetes mellitus. Hypertension was the primary risk factor, affecting 84% of patients, with 58% being male and 26% female (Figure 2a). Among these patients, 44% had controlled hypertension through medication, 31% were uncontrolled hypertensives, and 9% were newly diagnosed (denovo) hypertensives (Figure 2b). Diabetes was the second major risk factor, present in 53% of patients, comprising 37% male and 16% female (Figure 2c). Within the diabetic group, 13% had controlled diabetes, 36% were uncontrolled diabetics, and 4% were newly diagnosed (denovo) diabetics (Figure 2d). Our further analysis revealed that approximately 81% of patients had an awareness of stroke, while 19% lacked any knowledge about it (Figure 2e).

 

Figure 2: Risk Factors associated with stroke, (a) Gender distribution of patients with hypertension; (b) Hypertension control status among patients; (c) Gender distribution of patients with diabetes; (d) Diabetes control status among patients; (e) Awareness of stroke among patients.

 

Triggers

The study primarily investigated the triggers observed on the day of stroke onset. It was found that 65% of patients had no identifiable triggers. Among those with triggers, 6% experienced financial stress, another 6% encountered work-related stress, and 6% reported missing medication or having a fever/infection as contributing factors. Additionally, 4% of patients experienced anger prior to stroke onset, while 2% reported headache and family stress. Notably, chain smoking, alcohol binge, and sad emotional stress were identified as triggers in 3% of the study population (Figure 3a).

 

Figure 3: Potential triggers for the onset of stroke, triggers observed on the day of stroke onset.

 

Discussion

India faces a staggering burden of stroke, with over 15 lakh new cases annually (almost 4,000 daily) due to a lack of awareness about stroke symptoms, risk factors, and the “golden hour” for timely intervention [12]. Our study provides essential insights into the prevalence and distribution of both existing and newly identified (denovo) risk factors for stroke, which could aid in disease management. Additionally, this study evaluated triggers on the day of stroke occurrence to understand their impact on the onset or severity of stroke.

 

The study revealed that ischemic stroke was the most prevalent type of stroke observed, followed by haemorrhagic stroke. The underlying mechanisms driving these two types of strokes were distinctly different. Intracranial atherosclerosis emerged as the primary mechanism for ischemic stroke, wherein the build-up of fatty deposits within the arteries led to restricted blood flow to the brain [13]. On the other hand, hypertension was identified as the leading cause of hemorrhagic stroke, where elevated blood pressure resulted in the rupture of small blood vessels within the brain [14].

 

A critical finding of our study was the significant impact of undetected (denovo) and uncontrolled hypertension and diabetes mellitus as a major contributor to stroke in our cohorts. Our findings were consistent with existing literature [15], as we discovered that 9% and 4% of our patients were diagnosed with denovo hypertension and diabetes mellitus, respectively, following the onset of stroke. Furthermore, the study highlighted a concerning prevalence of uncontrolled chronic conditions within our patient cohort. Specifically, 31% of patients had uncontrolled hypertension, and 36% had uncontrolled diabetes mellitus. These uncontrolled conditions are likely to have played a significant role in elevating the risk of stroke in these individuals [8].

 

The role of acute triggers in the onset of stroke has been a subject of increasing interest, complementing the well-established understanding of chronic risk factors such as hypertension and diabetes mellitus [16]. In our study, we observed that approximately 29% of patients experienced significant stress—be it financial, work-related, emotional, or familial - on the day of stroke. Additionally, 6% of patients reported missing essential medications or having recent infections as immediate precipitating factors. Our findings align with existing literature that identifies stress as a significant, albeit often underrecognized, contributor to stroke incidence [16]. Studies have demonstrated that individuals experiencing high levels of psychosocial stress have a markedly increased risk of both ischemic and hemorrhagic strokes [17]. The INTERSTROKE study [10], identified stress and stressful life events as important risk factors for acute stroke across diverse populations. Our findings thus emphasize the significant impact of modifiable acute triggers such as stress, medication non-adherence, and infections on stroke incidence. Addressing these through targeted interventions, such as stress reduction, mental health support, patient education, and infection control, could reduce stroke rates and improve outcomes.

 

Our study revealed that while most patients were aware of stroke symptoms and risk factors, a small percentage lacked awareness, potentially delaying symptom recognition and medical care, leading to poorer outcomes. Bridging this gap through community education, informational materials, and local media can enhance awareness, prompt timely interventions, and improve stroke management, ultimately reducing incidence and improving outcomes.

 

Conclusion

Our study emphasizes the significant impact of hypertension, diabetes, and various triggers on stroke occurrence. Ischemic strokes were notably more prevalent, occurring nearly four times more often than haemorrhagic strokes. A key finding of our study was the substantial contribution of denovo hypertension and diabetes mellitus, along with poorly managed cases of these conditions to stroke incidence. Stress in its various forms emerged as a major trigger, though a considerable number of patients reported no identifiable triggers. These findings emphasize the need for heightened awareness and proactive management of stroke risk factors across all demographics. Future research with larger sample sizes is essential to further validate and expand upon these findings.

 

Acknowledgement

We would like to extend our sincere gratitude to all the patients and their caregivers who participated in this study.

 

Conflict of interest

There is no conflict of interest to declare.

 

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