Case Report
2022 June
Volume : 10 Issue : 2


A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy

Tanwar VS, Singh AA, Tank R, Saini A, Jatana S, Singh S

Pdf Page Numbers :- 105-108

Vikram Singh Tanwar1,*, Anurag Ambroz Singh1, Rakesh Tank1, Anjali Saini1, Sugam Jatana1 and Shobhit Singh1

 

1Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India

 

*Corresponding author: Dr. Vikram Singh Tanwar, Associate Professor, Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India. Email: drvikrampgi@gmail.com

 

Received 1 February 2022; Revised 9 March 2022; Accepted 18 March 2022; Published 28 March 2022

 

Citation: Tanwar VS, Singh AA, Tank R, Saini A, Jatana S, Singh S. A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy. J Med Sci Res. 2022; 10(2):105-108. DOI: http://dx.doi.org/10.17727/JMSR.2022/10-20

 

Copyright: © 2022 Tanwar VS et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

View Full Text | PDF

Abstract

Antiphospholipid syndrome (APS) is an acquired autoimmune clinical disorder characterized by persistently raised levels of anti-phospholipid antibodies and clinical feature of hypercoagulability (recurrent vascular thrombosis and pregnancy morbidities). Primary APS is idiopathic in nature though secondary APS is associated with other connective tissue diseases like SLE. Here, we present an instance of primary APS with recurrent cerebral venous sinus thrombosis in a youthful unmarried female who clinically presented with generalized epilepsy. Level of anti-cardiolipin (aCL) and anti-beta 2 GP1 antibodies were found elevated on two occasions 12 weeks apart. The patient was treated with anticoagulation therapy along with anti-epileptic therapy and she responded well to the therapy. This case report highlights that clinicians should always suspect APS in female patients who had history of seizures and ischemic or thrombotic lesions on brain imaging, irrespective of presence of pregnancy comorbidities.

 

Keywords: antiphospholipid syndrome; cerebral venous; sinus thrombosis; epilepsy

Subscription