Evaluation of Trop 2 expression in thyroid lesions

Vani D, Lhamo T, Adil SAK

Pdf Page Numbers :- 39-43

Vani D¹, Tsering Lhamo¹ and Adil SAK^1,*

¹Department of Pathology, Mysore Medical College and Research Institute, Mysuru, Karnataka 570001, India

*Corresponding author: Dr. SAK. Adil, Assistant Professor, Department of Pathology, Mysore Medical College and Research Institute, Mysore, Karnataka 570001, India. Email: saka291@yahoo.co.in

Received 17 October 2024; Revised 3 December 2024; Accepted 10 December 2024; Published 17 December 2024

Citation: Vani D, Lhamo T, Adil SAK. Evaluation of Trop 2 expression in thyroid lesions. J Med Sci Res. 2025; 13(1):39-43. DOI: http://dx.doi.org/10.17727/JMSR.2024/13-7

Copyright: © 2025 Vani D et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: Thyroid lesions pose a significant health burden in the population with female preponderance. It is important to note that understanding Trop-2's role in PTC is still evolving, and further research is needed to fully elucidate its significance and potential implications in managing the disease. This study aimed to analyze the expression of Trop-2 in various thyroid lesions and its potential role in distinguishing papillary thyroid cancer from other thyroid tumors.

Materials and methods: Patient history was taken before sample collection. Then, a histomorphological diagnosis was made, followed by immunohistochemistry conduction using Trop-2 monoclonal antibodies. The membranous staining of the Trop-2 IHC was examined and compared. Statistical values were calculated along with the degree of significance.

Results: The overall sensitivity and specificity of Trop-2 staining in diagnosing PTC were found to be 85.71% and 94.4%, respectively. The current study's findings were compared with those of previous studies done by scholars.

Conclusion: Trop-2 IHC aids in the diagnosis of PTC from other non-PTC thyroid lesions. It has tremendous diagnostic potential for PTC, as claimed by previous studies.

Keywords: immunohistochemistry; papillary thyroid carcinoma; trophoblastic antigen-2; Trop-2