Exploring the pediatric lymphoma landscape: State cancer institute experience

Shah SS, Brahmbhatt B, Parikh B, Maru P, Phalak P, Trivedi P

Pdf Page Numbers :- 6-11

Shaini Shailesh Shah¹, Beena Brahmbhatt^1,*, Biren Parikh¹, Paheli Maru¹, Pooja Phalak¹ and Priti Trivedi¹

¹Department of Oncopathology, The Gujarat Cancer and Research Institute, Ahmedabad 380016, Gujarat, India

*Corresponding author: Dr. Beena Brahmbhatt, Associate Professor, Oncopathology Department, The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad - 380016, Gujarat, India. Email: beena.brahmbhatt@gcriindia.org

Received 30 September 2024; Revised 13 November 2024; Accepted 21 November 2024; Published 2 December 2024

Citation: Shah SS, Brahmbhatt B, Parikh B, Maru P, Phalak P, Trivedi P. Exploring the pediatric lymphoma landscape: State cancer institute experience. J Med Sci Res. 2025; 13(1):6-11. DOI: http://dx.doi.org/10.17727/JMSR.2024/13-2

Copyright: © 2025 Shah SS et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PDF

Abstract

Background: Pediatric lymphoma is the third most prevalent childhood malignancy in India. The diverse nature of lymphoma in the pediatric age group emphasizes the need for personalized treatment strategies. This study aimed to highlight histomorphological subclassification of pediatric lymphoma and analyze the distribution of nodal and extranodal lymphoma. Materials and

Methods: In a retrospective observational study done over a period of three and a half years, 126 cases of pediatric lymphomas were diagnosed with the help of histomorphology and immunohistochemistry (IHC).

Results: A total of 126 pediatric patients were enrolled in our study. Non-Hodgkin lymphoma (NHL) comprised 53.2% and Hodgkin lymphoma (HL) accounted for 46.8% with a male to female ratio of 2.7:1. T lymphoblastic lymphoma was the most prevalent (46.3%) and thoracic cavity was the most common extranodal site for it. The most common subtype of HL reported was mixed cellularity (56%).

Conclusion: Comprehensive morphological assessment and targeted IHC profiling are essential for precise subclassification of both nodal and extranodal pediatric lymphoma. Recent progress in pediatric lymphoma research has optimized treatment strategies.

Keywords: childhood malignancy; Hodgkin lymphoma; non-Hodgkin; pediatric