Uncharted territory: Unusual metastasis of cervical squamous cell carcinoma to uterine corpus, bilateral fallopian tubes and periadnexal tissue

Vani D, Bhanusree Y, Dayananda R

Pdf Page Numbers :- 69-72

Vani D¹, Bhanusree Y^1,* and Rohan Dayananda¹

¹Department of Pathology, Mysore Medical College and Research Institute, Mysuru, Karnataka 570001, India

*Corresponding author: Dr. Bhanusree Y, Department of Pathology, Mysore Medical College and Research Institute, Mysuru, Karnataka 570001, India. Email: yeggadibhanusree@gmail.com

Received 27 January 2026; Revised 10 March 2026; Accepted 22 March 2026; Published 28 March 2026

Citation: Vani D, Bhanusree Y, Dayananda R. Uncharted territory: Unusual metastasis of cervical squamous cell carcinoma to uterine corpus, bilateral fallopian tubes and periadnexal tissue. J Med Sci Res. 2026; 14(2):69-72. DOI: http://dx.doi.org/10.17727/JMSR.2026/14-13

Copyright: © 2026 Vani D et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Introduction: Cervical squamous cell carcinoma (SCC) is the fourth most common malignancy among women worldwide and remains a major cause of cancer-related morbidity and mortality in developing countries. Cervical SCC commonly spreads through lymphatic and hematogenous routes; however, superficial or horizontal spread to the uterine corpus and adnexal structures is exceptionally rare. We report a rare case of cervical SCC with direct extension into the endometrium, myometrium, bilateral fallopian tubes, and periadnexal tissue.

Case presentation: A 60-year-old postmenopausal woman with postmenopausal bleeding was diagnosed with HSIL on cervical biopsy. Imaging demonstrated an enhancing anterior cervical lesion with cervical stenosis. Surgical resection revealed invasive squamous cell carcinoma of the cervix with extensive superficial ("carpet-like") spread involving the endometrium, myometrium, bilateral fallopian tubes, and periadnexal tissue. p16 block positivity across all involved sites supported a cervical origin.

Conclusion: This case highlights an unusual tumor spread of cervical SCC and emphasizes the importance of meticulous histopathological and immunohistochemical evaluation for accurate diagnosis and appropriate clinical management.

Keywords: cervical squamous cell carcinoma; horizontal spread; endometrial involvement; fallopian tube tumor spread; p16