A prospective study on correlation of cord blood bilirubin with occurrence of neonatal hyperbilirubinemia

Anjanappa S, Ansari TF, Unki P, Krishnegowda M

Pdf Page Numbers :- 104-108

Sandhya Anjanappa¹, Tazeem Fatima Ansari², Praveen Unki³ and Madhunandan Krishnegowda^1,*

¹Department of Pediatrics, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Karnataka, 571448, India

²Department of Pediatrics, SVD Sawarkar hospital, Mumbai-400081, Maharashtra, India

³Department of Pediatrics, Topiwala National Medical College and B.Y.L. Nair Charitable Hospital, Mumbai, Maharashtra, 400008, India

*Corresponding author: Dr. Madhunandan Krishnegowda, Assistant Professor, Department of Pediatrics, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Karnataka 571448, India. Email: madhunandangowda7@gmail.com

Received 16 December 2022; Revised 13 March 2023; Accepted 20 March 2023; Published 27 March 2023

Citation: Anjanappa S, Ansari TF, Unki P, Krishnegowda M. A prospective study on correlation of cord blood bilirubin with occurrence of neonatal hyperbilirubinemia. J Med Sci Res. 2023; 11(2):104-108. DOI: http://dx.doi.org/10.17727/JMSR.2023/11-20

Copyright: © 2023 Anjanappa S et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: Neonatal hyperbilirubinemia is one of the most common problems that can occur in a healthy new-born. This physiological rise in indirect component of bilirubin resolves gradually without any intervention in majority of cases. But few babies require intervention in the form of phototherapy and exchange transfusion when the bilirubin levels exceed the normal physiological range for gestational age. The study was aimed to evaluate the predictive value of cord blood bilirubin level for identifying newborn for development of significant hyperbilirubinemia.

Methods: It was a prospective observational study carried out in Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Karnataka. The cord blood bilirubin at birth and 48 hrs serum bilirubin levels were measured. Also, blood group, Rh status and DCT (direct coomb’s test) were tested to estimate the risk in development of hyperbilirubinemia.

Results: A total of 210 were included in the study, out of which 52 babies required phototherapy, with a sensitivity of 94.23% and specificity of 3.97%, with the mean cord blood bilirubin level of 2.6mg/dl, having sensitivity of 63.46% and specificity of 90.50%. The multivariate analysis showed ABO and Rh incompatibility, cord blood bilirubin level and lower gestational age had an increased the risk of hyperbilirubinemia requiring phototherapy.

Conclusions: Cord blood bilirubin may be used as a potential tool to determine hyperbilirubinemia in newborns. And initiation of phototherapy early in at-risk neonates may decrease the hyperbilirubinemia related morbidity and mortality.

Keywords: hyperbilirubinemia; cord blood bilirubin; phototherapy; newborn